International Takotsubo Registry (InterTAK Registry)

N/AUnknownNCT01947621

University of Zurich4,000 enrolled

Overview

This is a multicenter, multinational, prospective and retrospective, observational study of patients with Takotsubo cardiomyopathy (TTC). Data on natural profile (demographical characteristics, clinical phenotype, laboratory values, electrocardiography parameters, echocardiography parameters, coronary angiography parameters, medication) and outcome are systematically collected. Our aim is to gain a better insight into the clinical profile and pathophysiology of TTC.

Registry is an open-ended study and eligible individuals are assessed at index event and follow-up on their phenotypical characteristics. Furthermore, outcome data are collected (by clinical visits or telephone follow-up). In addition, participants are given the option to consent to the donation of biosamples for the purposes to identify TTC specific biomarkers and mutations (sub-study on behalf of the registry).

Study Type

OBSERVATIONAL

Enrollment

4,000

Conditions

Takotsubo Cardiomyopathy

Interventions

OTHER

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion criteria: Mayo Clinic Diagnostic Criteria (Prasad et al. American Heart Journal 2008) 1. Transient hypokinesis, akinesis, or dyskinesis of the left ventricular mid segments with or without apical involvement; the regional wall motion abnormalities extend beyond a single epicardial vascular distribution; a stressful trigger is often, but not always present.\* 2. Absence of obstructive coronary disease or angiographic evidence of acute plaque rupture. † 3. New electrocardiographic abnormalities (either ST-segment elevation and/or T-wave inversion) or modest elevation in cardiac troponin. In both of the above circumstances, the diagnosis of TTC should be made with caution, and a clear stressful precipitating trigger must be sought. \* There are rare exceptions to these criteria such as those patients in whom the regional wall motion abnormality is limited to a single coronary territory. † It is possible that a patient with obstructive coronary atherosclerosis may also develop TTC. Exclusion criteria: Patients with Myocarditis

Locations (1)

University Hospital Zurich, Division of Cardiology

Zurich, Canton of Zurich, Switzerland

RECRUITING

Outcomes

Primary Outcomes

Natural history of TTC

To determine the natural history of Takotsubo cardiomyopathy.

Time frame: 10 years

Secondary Outcomes

Cardiovascular complications, recurrence of TTC and all cause mortality

Patients will be assessed for cardiovascular complications during hospitalisation and at follow-up (up to 10 years)

Time frame: at hospitalizsation, short term (1 year) and long term (10 years)

Central Contacts

Christian Templin, MD, PhD

CONTACT

+41 44 255 95 85 christian.templin@usz.ch

Data from ClinicalTrials.gov

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