Cognitive Processes Study in Obese Women With and Without Eating Disorders

N/ACompletedNCT01948414

Hospices Civils de Lyon108 enrolled

Overview

The P300 is one of the cognitive wave of the Event-Related Potential (ERP) that is used to investigate the cognitive process. The P300 component are accepted as electro-physiological markers of neuropsychiatric disorders like alcoholism or drug addiction. Recent scientific data suggest that eating disorders, leading to weight gain and obesity, will be similar of those of drug addiction: it is the incentive sensitization theory that implicates the dopaminergic reward system. The aim of this cross-sectional study is to investigate the alteration of P300 auditory ERP in obese women with eating disorders in comparison with obese and lean women without eating disorders.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

108

Conditions

Hyperalimentation and Obesity

Interventions

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * women * Aged from 20 to 55 years * Fasting glycemia under 7mmol/L * Lean women : women with BMI from 18.5 to 24.5 and disinhibition score to Three-Factor Eating Questionnaire (TFEQ)lower or equal to 8 * Obese women without eating disorders : women with BMI higher or equal to 35 and disinhibition score to TFEQ lower or equal to 8 * Obese women with eating disorders : women with BMI higher or equal 35 and disinhibition score to TFEQ strictly higher to 8 Exclusion Criteria: * Subject not in compliance with the recommendations of French National Law in force * Medical history of diabetes and surgery history of obesity * Drug use that could affect the ERP recording * Hospital Anxiety and Depression scale : evaluation subscale (anxiety and/or depression) strictly higher to 11

Outcomes

Primary Outcomes

P300 amplitude

The auditory event-related potentials measure will be elicited with an auditory oddball paradigm. The activity will be recorded thanks to electroencephalography from frontal, central and parietal electrodes, using an electrode cap.

Time frame: At the beginning of the exploration visit (when patient is fasting) that will take place between 1 and 15 days after inclusion

Secondary Outcomes

Auditory ERP ( latency P300, amplitude and latency of N2 wave recorded from frontal, central and parietal electrode)

The technique of auditory ERP will be an auditory discriminated task paradigm

Time frame: fasting (up to 15 days)

assessment of dietary restraints and disinhibition

Participants will complete self-report questionnaires including Three-Factor Eating Questionnaire and Eating Disorders Inventory. The lean subjects should not have TFEQ disinhibition score more than 8. The obese subjects will be separated on two groups depending on TFEQ dishinibition score (strictly greater than 8, the obese with eating disorder, less than or equal 8, obese without eating disorder).

Time frame: fasting (up to 15 days)

glucose, insulin, leptin and ghrelin plasmatic rate

respectively reverse-phase high-performance liquid chromatography (RP-HPLC), ImmunoRadio Metric (IRMA) and ELISA assay

Time frame: fasting (up to 15 days)

dopamine D2 receptor Taq 1 polymorphism

Real time PCR

Time frame: fasting (up to 15 days)

Dietary intake and eating patterns

Women will be interviewed by dietician, using a 24 h food questionnaire with additional questions regarding health and eating habits

Time frame: At day 1 and at day 15

Cognitive Processes Study in Obese Women With and Without Eating Disorders

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes