Hypofractionation With Simultaneous Integrated Boost for Early Breast Cancer

Inclusion Criteria: * Histopathologically confirmed breast cancer operated by breast conserving surgery with clear margins * Indication to adjuvant radiotherapy including boost radiotherapy * Clearly identified primary tumor region preferably by radiopaque clips * Primary wound healing after breast conserving therapy without signs of infection * Pre- and/or postoperative chemotherapy and endocrine therapy were permitted when indicated * Written informed consent Exclusion Criteria: * Patients operated by mastectomy * No indication for boost radiation * Resection margins positive for disease or insufficient identification of the boost volume * Indication for radiotherapy of the regional lymph nodes * History of prior breast or thoracic radiotherapy * Extended postoperative seroma at the beginning of radiotherapy * Psychiatric disorders or psychological disabilities thought to adversely affect treatment compliance * Pregnant or lactating patients and woman of child bearing potential, who lacked effective contraception