The Comparison of Effect of Four Different Treatment Protocols on IVF Outcomes in Poor Responders Undergoing in Vitro Fertilization.

Phase 4UnknownNCT01948804

Pınar Özcan Cenksoy100 enrolled

Overview

The comparison of effect of four different treatment protocols: Antagonist/letrozole protocol, microdose flare-up protocol, Antagonist/clomiphene protocol, Antagonist on IVF outcomes in poor responders undergoing in vitro fertilization; a prospective randomized-controlled study.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

100

Conditions

Poor Responders Undergoing IVF

Interventions

GnrH Antagonist/letrozole protocol (Cetrotide; serono + Femara; Novartis Pharma AG)DRUG

microdose flare-up protocol (Lucrin; Abbott + Gonal F, Serono)DRUG

Antagonist/clomiphene protocol (Cetrotide; serono + Klomen, Kocak pharma)DRUG

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 44 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Criteria for definition of poor responders included at least one of the following 1. Anti müllerian hormone \<1.1 ng/ml and/or a previous poor ovarian response (≤3 oocytes with a conventional stimulation protocol). 2. Primary infertile patients 3. BMI≤30 kg/m2 were included this study. Exclusion Criteria: \-

Outcomes

Primary Outcomes

clinical pregnancy rates

Time frame: 6 months

Secondary Outcomes

total number of oocytes retrieved

Time frame: 6 months

Data from ClinicalTrials.gov

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