Biomarkers In Retinitis Pigmentosa (BIRP)

N/ACompletedNCT01949623

Johns Hopkins University100 enrolled

Overview

In this study, markers of oxidative stress will be measured in the aqueous humour and plasma of RP patients compared to controls.

People with Retinitis Pigmentosa have loss of night vision followed by loss of central vision due to damage and death of photoreceptors. One of the mechanisms causing damage is high levels of oxygen in the eye. This damage produces specific biomarkers which can be measured. In this study, these biomarkers will be assessed in people with Retinitis Pigmentosa and compared to controls.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Retinitis Pigmentosa

Interventions

Anterior Chamber (AC) tapOTHER

Aqueous Samples will be collected for measurement of biomarkers

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Signed informed consent and authorization of use and disclosure of protected health information * Age more than or equal to 18 years * For the study group, patients diagnosed with Retinitis Pigmentosa by the investigators * For the control group, patients undergoing vitreoretinal surgery for macular hole, epiretinal membrane, vitreomacular traction, retinal detachment, neovascular Age-related Macular Degeneration (AMD) and Diabetic Retinopathy will be eligible Exclusion Criteria: * Patients with active or suspected ocular or periocular infection

Locations (1)

Wilmer Eye Institute

Baltimore, Maryland, United States

Outcomes

Primary Outcomes

Aqueous levels of markers of oxidative stress in patients with RP and controls.

Time frame: 2 years

Data from ClinicalTrials.gov

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