The Possible Correlations Between the Genes Related to Pain Sensation and the Pain Sensitivity in the General Population

N/ACompletedNCT01950078

Xianwei Zhang1,533 enrolled

Overview

Objective: This study was conducted to explore the possible correlation between some gene related to pain sensation and individual basal pain perception and postoperative pain intensity in the general population. Methods: Patients receiving elective surgery under general anesthesia were recruited into this study. The investigators measured their preoperative pressure pain threshold (PPT) and pressure pain tolerance (PTO). Pain intensity at rest and movement after the operation was evaluated . And the PCA drug consumption were recorded. Also there were healthy college students volunteer be recruited into this study. The investigators measured their experimental pain sensitivity including pressure pain threshold (PPT) and pressure pain tolerance (PTO), etc. Then genotyping was carried out.

Subjects with the following diseases were excluded: known history of chronic disease, psychiatric diseases or communication disorders, diabetes mellitus, severe cardiovascular diseases, kidney or liver diseases with poor hepatic function, alcohol or drug abuse, heavy smoker, Pregnancy or at lactation period .

Study Type

OBSERVATIONAL

Enrollment

1,533

Conditions

Pain Surgery

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * •Aged 18-65 years * Receiving elective gynecological laparoscopic surgery * Anesthesiologists (ASA) physical status I or II * Agreed to participate the research Exclusion Criteria: * •History of chronic pain * Psychiatric diseases * Diabetes mellitus * Severe cardiovascular diseases * Kidney or liver diseases * Alcohol or drug abuse * Heavy smoker * Pregnancy or at lactation period * Disagree to participate to the research

Outcomes

Primary Outcomes

Preoperative Pressure Pain Threshold (PPT)

The probe of pressure algometer was positioned perpendicularly to the skin surface of the patient, and the investigator applied continuous pressure at approximately the same rate according to the visual LCD display on the algometer. subjects were asked to say "pain" when they started to feel pain during the stimulation. The value from the LCD was recorded as the pressure pain threshold.

Time frame: 30 minutes before the operation

Secondary Outcomes

Preoperative Pressure Pain Tolerance (PTO)

The probe of pressure algometer was positioned perpendicularly to the skin surface of the patient, and the investigator applied continuous pressure at approximately the same rate according to the visual LCD display on the algometer. subjects were asked to say "ok" when they started to feel the pain became intolerable during the stimulation. The value from the LCD was recorded as the pressure pain tolerance.