The Correlational Study of PPV in Various VT in Mechanically Ventilated Patients

N/ACompletedNCT01950949

Yi Liu69 enrolled

Overview

Mesquida, J et al showed there was a significant linear correlation between pulse pressure variations under tidal volume 6 ml/kg and 8 ml/kg in patients after the resuscitation phase of severe sepsis and septic shock. No study revealed the actual relationship between various PPV under different VT. So we hypothesized that there were relationship between various PPV in different tidal volume settings. The objective of this study was to examine the relationship between various PPV.

Study Type

INTERVENTIONAL

Allocation

Masking

NONE

Enrollment

Conditions

Respiration, Artificial

Interventions

300 ml Hydroxyethyl Starch 130/0.4 and Sodium Chloride Injection infusing in 15 minutes if PPV under VT 8 ml/kg was larger than 13% in the initial investigationOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: scheduled for elective abdominal surgeries ASA (American Society of Anesthesiologists) I or II BMI 18-25 preoperative examination is normal Exclusion Criteria: acute lung injure acute respiratory distress syndrome cardiovascular diseases neurological disease renal or hepatic disease diabetes mellitus BMI less than 18 kg/m2 or greater than 25 kg/m2

Outcomes

Primary Outcomes

invasive arterial blood pressure as a Measure of Safety

if instability of circulation, stop the clinical trial

Time frame: Day 1

Data from ClinicalTrials.gov

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