Intra Amniotic Injection of DIGOXIN for Feticide in Second Trimester Termination of Pregnancy

Phase 3UnknownNCT01951079

Meir Medical Center100 enrolled

Overview

In second trimester abortion above 22 weeks the investigators usually inject intra-cardiac Kcl for feticide. Digoxin intra-amniotic injection has been described in the literature in doses of 1-1.5 mg. with a success rate of about 80%, and up to 24 weeks. Our aim in this study is to investigate the safety and success rate of 1.5-2 mg. digoxin, intra-amniotic up to 30 weeks pregnancy .

* The digoxin will be injected intra-amniotic with U.S guided, trying to avoid any placental passage or intravascular injection / * Any patient will have prior to the procedure a full examination including E.C.G and cardiac clearance.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

100

Conditions

Arrhythmia ECG Changes Hypotension

Interventions

Intra-amniotic injection of DIGOXINDRUG

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy women with no medical, cardiac, hypertension, liver or renal problems - pregnant in their 20-30 week gestation, * that need to have abortion due to fetal anomalies or any other reason * need to have feticide prior to the procedure Exclusion Criteria: * any patient with medical problem that may be a contra-indication to Digoxin * cardiac problems, * prior cardiac surgery, * liver or kidney disease, * hyper tension etc.