Impact of Fluid Milk on Post-meal Glycemia and Insulinemia in Overwt/Obese Adults

N/ACompletedNCT01951287

Purdue University54 enrolled

Overview

Blood sugar and insulin levels after a meal may be altered by the food and beverages a person consumes. Keeping a healthy blood sugar level may help prevent and manage type 2 diabetes and related diseases. This study will look at how drinking different common beverages (milk, low-fat milk, nonfat milk, orange juice, coffee, and water) with a meal changes blood sugar and insulin levels.

The broad aim of the proposed research is to evaluate the effects of consuming milk and non-milk beverages with a breakfast meal on postprandial glucose and insulin responses in overweight and obese adults with varying levels of glucose tolerance (normal, pre-diabetic, type 2 diabetes). The investigators expect the consumption of fluid milk with breakfast to decrease the postprandial glucose response relative to other non-milk beverages (orange juice and sweetened coffee). Furthermore, the investigators expect that there will be no difference in the postprandial glucose or insulin response between varieties of fluid milk (skim, low-fat, and whole).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Blood Glucose Blood Insulin

Interventions

Acute beverage (water) consumptionOTHER

Acute beverage consumption includes water.

Acute beverage (Black Coffee) consumptionOTHER

Acute beverage consumption includes black coffee.

Acute beverage (Orange Juice) consumptionOTHER

Acute beverage consumption includes Orange Juice..

Eligibility

Sex: ALLMin age: 35 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 35-65 years old, * BMI between 27-40 kg/m2, * HbA1C less than 7.5%, * weight stable (± 4.5 kg) for the previous 3 months * willing to consume study foods and beverages. Exclusion Criteria: * using exogenous insulin, * currently (or within the past 6 months) following a vigorous exercise regimen, or weight loss program, * acute illness, * smoking, * pregnant or planning pregnancy in the next 3 months, * lactose intolerant, * weight changes of greater than ± 3 kg during the study period

Locations (1)

Purdue University

West Lafayette, Indiana, United States

Outcomes

Primary Outcomes

plasma glucose levels

Subjects will come to testing once a week for six weeks. Each testing day, subject will come in fasted, and a fasting blood draw will be taken. Subjects will then be fed a standard breakfast with one of the 6 beverages (coffee sweetened with sugar, orange juice, water, whole milk, skim milk, low fat milk). Blood will be taken at 30, 60, 60, 90, 120, 150,180,210,240 minutes after the meal.

Time frame: 6 mornings separated by at least a week, fasting and 30, 60, 60, 90, 120, 150,180,210,240 minutes postprandial

Secondary Outcomes

Plasma Insulin Levels

Time frame: 6 mornings separated by at least a week, fasting and 30, 60, 60, 90, 120, 150,180,210,240 minutes postprandial

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.