Korean Red Ginseng Rg3 Extract on Arterial Stiffness and Blood Pressure

Phase 1CompletedNCT01951443

Unity Health Toronto24 enrolled

Overview

The purpose of the study is to evaluate the acute effect of a standardized extract of KRG (Rg3-KRG) consisting of 30% total ginsenosides, including 10% Rg3 ginsenoside on arterial stiffness and blood pressure, as measured by the following parameters: aortic augmentation index, peripheral blood pressure, central blood pressure

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Arterial Stiffness, Blood Pressure

Interventions

GinsengDIETARY_SUPPLEMENT

400mg of encapsulated Rg3-KRG

Wheat BranDIETARY_SUPPLEMENT

400mg of encapsulated wheat bran

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy * Age 18-70 years * BMI \< 30 kg/m2 * Brachial systolic blood pressure \< 140 mmHg * Brachial diastolic blood pressure \< 90 mmHg Main Exclusion Criteria: * BMI \>30kg/m2 * Hypertensive (brachial systolic BP ≥140mmHg and/or diastolic BP ≥90mmHg) * Pregnancy

Locations (1)

Risk Factor Modification Centre, St. Michael's Hospital

Toronto, Ontario, Canada

Outcomes

Primary Outcomes

To evaluate the acute effect of Rg3-KRG on arterial stiffness in healthy adult volunteers, as measured by aortic augmentation index (AIx).

Time frame: Two weeks (measurements taken on two separate visits with minimum one week washout)

Secondary Outcomes

To evaluate the acute effect of Rg3-KRG on aortic and brachial blood pressure in healthy adult volunteers.

Time frame: Two weeks (measurements taken on two separate visits with minimum one week washout)

Data from ClinicalTrials.gov

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