Oocyte Survival After Vitrification in an Open or Closed Device With Closed Storage.

N/ACompletedNCT01952184

Universitair Ziekenhuis Brussel48 enrolled

Overview

The survival rate (and embryo quality) of donor oocytes with two commercially available devices.

Donor sibling oocytes will be vitrified with two commercially available devices. The first device is closed vitrification with closed storage and the second device is open vitrification with closed storage. Oocyte acceptors receive oocytes from both devices. With the increase in cooling rate generated by the open vitrification (second device), we expect to get an increase in survival rate of 10%. Besides this, embryo quality will be assessed with oocytes obtained from both devices.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Survival Embryo Quality

Interventions

CBSvit HS deviceDEVICE

closed vitrification with closed storage

Cryotop SC deviceDEVICE

open vitrification with closed storage

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 36 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Donor: ≤36 years old on day of oocyte retrieval * Donor: ≥ 6 mature oocytes Exclusion Criteria: * Donor: \< 6 mature oocytes

Locations (1)

Universitair Ziekenhuis Brussel

Jette, Brussels Capital, Belgium

Outcomes

Primary Outcomes

Survival rate

The purpose is to assess the survival rate of donor oocytes with the two vitrification devices.

Time frame: up to 6 days after every warming cycle

Secondary Outcomes

Embryo development

The purpose is to analyse the pre-implantation development of donor oocytes vitrified with two different devices.

Time frame: up to 6 days after every warming cycle

Data from ClinicalTrials.gov

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