The purpose of this study is to determine the impact of diet and physical exercise program on pregnancy rate and live birth in obese women who undergo an IVF cycle.
The objective of this study is showing that obesity significantly affects the in vitro fertilization cycles lowering the reproductive capacity. The study is been performed in Hospital de la Santa Creu i Sant Pau and Fundació Puigvert of Barcelona. Patients recluted are obese women with sterility problems that require in vitro fertilization (IVF) with a body mass index BMI between 30-35. It´s a randomised study in which half of the patients undergo to a 6 weeks program of diet and exercice. We will analyse the response to ovaric stimulation, the results of the egg retrieval (ovocyte number and quality), rates of fecundation, embryo implantation and clinical gestation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
41
Total caloric intake aimed at maintaining a diet with\> 50% of the caloric content in the form of carbohydrates, less than 10% in the form of saturated fats and 20% from monounsaturated / polyunsaturated (if applicable, up to 25% fat monounsaturated), less than 300 mg / day of dietary cholesterol and about 1.0 g of protein / kg ideal body weight / day.
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
Pregnancy rate
Pregnancy rate by cycle
Time frame: 14 days after embryo transfer
Hyperstimulation rate
Number of patients with moderate or severe hyperstimulation
Time frame: At luteal phase and first weeks of pregnancy
Fertility rate
Rate of mature oocytes fertilized by conventional IVF or ICSI
Time frame: 24 hours post pick up
Mature oocytes
Number of total mature oocytes obtained after stimulation
Time frame: Pick up day
Cancellation rate
Stimulated Patients who fail to perform the follicular puncture
Time frame: Durinf the stimulation in follicular phase
Good quality embryos
Number of good quality embryos obtained (A and B) by patient
Time frame: Day 3 to 5 post pick up
Abortion rate
Number of non evolutive pregnancies during the first trimester
Time frame: First trimester of pregnancy
Live birth rate
Amount of patients who finish the treatment with a live newborn
Time frame: Between 7 a 9 months after treatment
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