Effect of Medium Chain Triglyceride Consumption on Appetite

N/ACompletedNCT01952977

St. Luke's-Roosevelt Hospital Center17 enrolled

Overview

The purpose of this study is to test the effects of medium chain triglyceride consumption, relative to long chain triglycerides, on hormones involved in appetite regulation and food intake in overweight men. We expect medium chain triglycerides to reduce appetite and food intake and to do so by increasing levels of hormones known to be involved in satiety and reduce levels of those involved in appetite.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

SINGLE

Enrollment

Conditions

Obesity

Interventions

Test breakfastDIETARY_SUPPLEMENT

Eligibility

Sex: MALEMin age: 19 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Males * Weight stable (\<10 lb over previous 3 months) * Overweight (body mass index 25-29.9) Exclusion Criteria: * Smokers * Excessive caffeine users * Severe health conditions * Allergy to food products/ingredients in the study * Taking medications known to affect energy expenditure or gastrointestinal function

Locations (1)

New York Obesity Nutrition Research Center

New York, New York, United States

Outcomes

Primary Outcomes

Food intake

Intake at an ad libitum meal 3 h after test oil consumption (Study 1) or 1 h after a pre-load containing the test oil (Study 2)

Time frame: up to 3 hours

Secondary Outcomes

Ghrelin

Time frame: 3 hours

Peptide YY

Time frame: 3 hours

Glucagon-like peptide 1

Time frame: 3 hours

Insulin

Time frame: 3 hours

Triglycerides

Time frame: 3 hours

Leptin

Time frame: 3 hours

Data from ClinicalTrials.gov

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