The purpose of this study is to assess the impact of different parameters (voltage, pulse width, frequency) of subthalamic nucleus (STN) deep brain stimulation (DBS) on motor symptoms in patients with Parkinson's disease (PD).
In this observational study, we will retrospectively analyze the one-year follow-up data of 27 PD patients who received bilateral STN DBS in the First Affiliated Hospital of Sun Yat-sen University in the years 2008-2012. The data, including parameter settings and severity of motor symptoms indicated by Unified Parkinson's Disease Rating Scale (UPDRS) Part III scores, was collected during the patients' annual visit to the hospital for reprogramming. A correlation analysis will be conducted to investigate the relationship between change of a specific parameter and the subsequent change of motor scores.
Study Type
OBSERVATIONAL
Enrollment
27
First Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China
Change of parameters (voltage, pulse width, frequency) during follow-up
Time frame: at 12 months
Change of UPDRS Part III score and the relation to parameters
Time frame: at 12 months
Changes of tremor, rigidity, bradykinesia and postural stability scores evaluated by UPDRS Part III and the relation to parameters
Time frame: at 12 months
Change of daily levodopa equivalent dosage (LED) during follow-up
Time frame: at 12 months
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