The purpose is to study: 1. the frequency of vitamin D deficiency at patients with tibial fracture treated with an external ring fixator 2. if vitamin D supplement facilitates fracture healing 3. a possible relation between vitamin D deficiency and the risk of complications and the time of fracture healing
External ring fixator is a widespread and well-known method to treate complex tibial fractures. The effect of treating proximal and distal intra-articulatio tibial fractures has been positive until now. Complications such as malunions, nonunions, re-fractures and extended time of ring fixation will occur in 5-10% of all tibial fractures in patients treated with ring fixator. Factors like trauma of soft tissue, smoking and compromised afflux of blood are associated with a higher frequency of nonunion. It has been documented that elderly people with hypovitaminosis D have a higher risk of being affected by osteoporosis and fractures. Furthermore, there is a possible association between the severity of fracture and hypovitaminosis. The time of fracture healing is also extended compared to fractures in patients who are not affected by osteoporosis. Until now research has not shown whether the fracture healing process is influenzed by vitamin D.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
130
Aalborg University Hospital
Aalborg, Region Northern Jutland, Denmark
Time of fracture healing
Time of fracture healing, i.e. time from osteosynthesis until fracture healing is clinically and radiologically registered.
Time frame: 20 weeks
Vitamin D receptor DNA
A DNA blood sample will be taken in order to analyse how the skeleton reacts on vitamin D supplement.
Time frame: 20 weeks
Complications
Registration of possible complications, i.e. nonunion, malunion, number of check-ups, infections, re-surgery.
Time frame: 20 weeks
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