Chronic Effects of Two Aerobic-training Models Performed in Water and on Dry Land in Patients With Type 2 Diabetes Mellitus (T2DM).

N/ACompletedNCT01956357

Hospital de Clinicas de Porto Alegre35 enrolled

Overview

The aim of this study was to analyse the acute and chronic effects of two aerobic-training models performed in water and on dry land on cardiorespiratory, functional, metabolic, hormonal and quality-of-life parameters in patients with type 2 diabetes mellitus (T2DM).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Diabetes Mellitus, Type 2

Interventions

Aquatic exerciseOTHER

Land ExerciseOTHER

Eligibility

Sex: ALLMin age: 30 Years

Medical Language ↔ Plain English

Inclusion Criteria: The clinical diagnosis of type 2 diabetes mellitus. Not be performing regular and systematic physical exercise for at least three months. Exclusion Criteria: Uncontrolled hypertension. Autonomic neuropathy. Severe peripheral neuropathy. Proliferative diabetic retinopathy. Severe nonproliferative diabetic retinopathy. Uncompensated heart failure. Peripheral amputations. Chronic renal failure (GFR by MDRD \<30). Muscle or joint injury that prevents physical exercises.

Locations (1)

Physical Education School of Federal University of Rio Grande do Sul

Porto Alegre, Rio Grande Do Sil, Brazil

Outcomes

Primary Outcomes

Glycated hemoglobin

Time frame: Baseline and after 12 weeks of intervention

Secondary Outcomes

Fasting plasma glucose.

Time frame: Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.

Postprandial glucose

Time frame: Baseline and after 12 weeks of intervention.

Fasting insulin.

Time frame: Baseline and after 12 weeks of intervention.

Insulin resistance (HOMA-IR).

Time frame: Baseline and after 12 weeks of intervention.

Total cholesterol.

Time frame: Baseline and after 12 weeks of intervention.

High density lipoprotein.

Time frame: Baseline and after 12 weeks of intervention.

Low density lipoprotein.

Time frame: Baseline and after 12 weeks of intervention.

Triglycerides.

Time frame: Baseline and after 12 weeks of intervention.

Plasma renin activity.

Time frame: Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.

Angiotensin II.

Time frame: Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.

C-reactive protein ultrasensitive.

Time frame: Baseline and after 12 weeks of intervention.

8-isoprostane

Time frame: Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.

Content of reative species (DCF)

Time frame: Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.

Water-soluble Fluorescent Substances

Time frame: Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.

Oxidation of tyrosine residues

Time frame: Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.

Oxidation of tryptophan

Time frame: Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.

superoxide dismutase (SOD)

Time frame: Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.

Catalase (CAT)

Time frame: Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.

Glutathione peroxidase (GPX)

Time frame: Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.

Total radical-trapping antioxidant potential (TRAP)

Time frame: Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.

Interleukin 1β

Time frame: Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.

Interleukin 10

Time frame: Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.

Leukocyte DNA Methylation

Time frame: Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.

Purines

Time frame: Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.

Interleukin 6

Time frame: Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.

Global Histone Deacetylases activity

Time frame: Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.