The purpose of this study is to evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) as a method to increase the biomechanical and biochemical stability of the cornea by inducing additional cross-links within or between collagen fibers using UVA light and the photo- mediator riboflavin.
This study will evaluate the results of Corneal Collagen Crosslinking (CXL) in patients with conditions that include Keratoconus, Pellucid Marginal degeneration, Post-LASIK ectasia, and patients with radial keratotomy who experience fluctuation in their vision. This is an outcomes study, all patients receive treatment.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
1,324
Corneal Collagen cross linking with UV light and riboflavin
Center for Excellence in Eye Care
Miami, Florida, United States
Stulting Research Center at Woolfson Eye Institute
Atlanta, Georgia, United States
TLC Laser Eye Center
Rockville, Maryland, United States
Talamo Hatch Laser Eye Consultants, LLC
Boston, Massachusetts, United States
Change in Best Spectacle Corrected Visual Acuity (BSCVA)
Time frame: 6-9 months
Change in Uncorrected Visual Acuity (UCVA)
Time frame: 6-9 months
Change in Corneal topography
Time frame: 6-9 months
Change in Manifest Refraction
Time frame: 6-9 months
Change in Keratometry on topography and Pentacam
Time frame: 6-9 months
Change in Wavefront Refraction and aberrations
Time frame: 6-9 months
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Cleveland Eye Clinic
Brecksville, Ohio, United States
TLC Laser Eye Center
Fairfax, Virginia, United States