Assessment of Normal Values of Esophagogastric Junction (EGJ) Distensibility in Healthy Volunteers

Inclusion Criteria: 1. No history of gastrointestinal disease, especially gastro-esophageal reflux disease 2. BMI = 18-30 kg/m² 3. Caucasian race 4. Subject signed the informed consent form and is able to adhere to study protocol Exclusion Criteria: 1. Age \< 18 years 2. Previous esophageal or gastric surgery 3. Co-morbidities (including cardiopulmonary disease, collagen diseases, obesity, coagulation disorders and co-morbidity hindering upper gastrointestinal endoscopy) 4. Patients using anticoagulants 5. Patients unable to give informed consent 6. Smoking 7. History of alcohol abuse or current excessive alcohol consumption (\> 2 alcoholic beverages per day or \> 14 alcoholic beverages per week)