Phase II Study of HPV Therapeutic Vaccine in HPV Infected Women With Normal Cytology or ASCUS/LSIL

Inclusion Criteria: * A subject will be eligible for inclusion in this study if the following criteria apply: 1. Subject is female between the ages of 25 and 50 years (inclusive). 2. Subject is pre-menopausal . 3. Subject must have cervical HPV 16 and/or 18 infection confirmed by RT-PCR 4. Subject has a cervical cytological evaluation with a normal, ASCUS or LSIL result at baseline. 5. Subject has employed highly effective contraception the month prior to the first vaccination and will agree to employ highly effective contraception for at least 12 months after the first vaccination. . 6. Subject is in general good health based on medical history and physical examination. 7. Subject is able to communicate effectively with study personnel and is considered reliable, willing, and cooperative in terms of compliance with the protocol requirements. 8. Subject voluntarily gives written informed consent to participate in the study. Exclusion Criteria: 1. Subject has a current acute or chronic disease, other than infection with HPV, which would be expected to interfere with the planned evaluations of response 2. Subject has vaginal atrophy with or without topical hormonal therapies or systemic selective estrogen receptor modulators (SERMs). 3. Subject has prior exposure to HPV prophylactic vaccine or subject has participated in the past in another vaccination clinical trial related to infection with HPV 4. Current high grade lesions or history of untreated high grade cervical lesion (either CIN2 or CIN3). 5. Subject has current or a history of cancer of the cervix. 6. Subject has clinically significant (CS) gynaecological abnormalities that could interfere with study evaluation, in the judgment of the Investigator (e.g. prolapse, myoma, fibroid, hysterectomy). 7. Subject has a laboratory abnormality Grade ≥ 2, as defined using the Toxicity Grading Scale for Healthy Adult and Adolescent Volunteers Enrolled in Preventative Vaccine Clinical Trials, 8. Subject has received any live viral vaccine within 3 months or any other non live vaccine within 2 weeks of first study product administration. 9. Subject has primary or secondary systemic immunosuppression 10. Subject has a history of severe allergy (requiring hospital care) or history of severe asthma 11. Subject has a history of malignant cancer, except the following adequately treated cancers: basal cell carcinoma, or dermatological squamous cell carcinoma. 12. Subject was administered with another investigational drug or vaccine within 30 days prior to the screening visit or is participating in any other study. 13. Subject has a known hypersensitivity to imiquimod. 14. Subject has a history of severe reaction to any drug or vaccination. 15. Subject has a medical condition with clinical and/or biological consequences judged by the Investigator incompatible with vaccination(s). 16. Subject has positive results for human immunodeficiency virus (HIV), hepatitis B virus (HBV) surface antigen (HBsAg), or hepatitis C virus (HCV). 17. Subject has a symptomatic vaginal or genital infection 18. Subject has a history of or currently active genital herpes disease. 19. Subject is pregnant or is breastfeeding. 20. Subject has a positive serum human chorionic gonadotrophin (HCG) result at enrolment.