The study Aims to investigate the possible beneficial impact of peri-operative or post-operative administration of Omega 3 enriched lipid emulsions on recipients for living donor liver transplantation.
Patients will be divided intro three groups, A control group will receive equivalent volume of glucose 10% solution both 3 days before and 5 days after the operation . A peri-operative groups, in which patients will receive omega 3 enriched lipid emulsion (SMOFLipid) for 2 days pre-transplantation and 5 days post-transplantation A Post-operative group, in which patients will receive glucose 10% 3 days before the operation and omega 3 enriched lipid emulsion (SMOFLipid) for 5 days post-transplantation The primary outcome objective will be the incidence of Ischemia re-perfusion injury, secondary outcomes includes post-operative complications, graft and patient's outcomes and graft regeneration
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
114
Patients will receive same dose of 10% glucose solution for 2 days pre operatives and 5 days post-operative
Liver transplantation program - Gastroenterology surgical center - Mansoura university
Al Mansurah, Dakahlia Governorate, Egypt
RECRUITINGIschemia reperfusion injury
Time frame: 5 days
Liver functions
Time frame: 5 days
Early graft regeneration
assessment of percent of liver regeneration 1 month PO
Time frame: one month
Late graft regeneration
assessment of percent of liver regeneration 13 months PO
Time frame: 3 month
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