Dysfunctions and Plasticity Mechanisms of Motor System Assessed by Cortico-cortical and Cortico-muscular Coherence Analysis in Amyotrophic Lateral Sclerosis

Inclusion Criteria: * Patient female or male, more than 18 years, * Patien with a diagnosis of amyotrophic lateral sclerosis according to the El Escorial criteria of Brooks et al. 1994 * Patient , the beginning of the SLA date less than 12 months, * Patient not having a familial form of ALS, * Patient not having cancer, autoimmune disease, liver failure, severe hypertension or untreated, severe conduction disorders or uncontrolled arrhythmia * Patient not having a chronic psychiatric disease, dementia. * Patient with normal visual function * Patients receiving social coverage * Patient have read, understood and signed an informed consent after information Exclusion Criteria: * Patient minor * Patient with a familial form of ALS, * Patient associated with severe progressive disease (cancer, autoimmune disease , liver failure ) * Patient (s) with chronic mental illness, dementia , * Presence of atypical clinical signs such as cerebellar ataxia , extrapyramidal signs, sensory disorders , autonomic dysfunction . * Clinical signs of chronic respiratory failure or slow and / or forced less than 70% of the theoretical value or chronic hypercapnia than 45 mmHg vital capacity . * Patient private freedom following a judicial or administrative decision * Patient major Trust * Pateinte pregnant, parturient , lactating * Patient major in legal protection ( guardianship ) * Pateinte pregnant , parturient , lactating * Patient hospital without consent * Patient admitted in a health or social establishment for purposes other than research