Safety, Reactogenicity and Immunogenicity of Flublok Quadrivalent (Recombinant Influenza Vaccine,Seasonal Formulation)

Inclusion Criteria: 1. Male or female age 6-17 years (Cohort A: 6-8 years of age; Cohort B: 9-17 years of age) 2. Female subjects of child-bearing potential (as defined by the onset of menses) must agree to avoid becoming pregnant and to use effective method of contraception or practice abstinence for at least 28 day prior to the first study vaccine administration, until the completion of the study. Female subjects of child-bearing potential must have a negative pregnancy test within 24 hours prior to vaccine administration. 3. In good general health, as determined by medical history and targeted physical examination, if indicated The parent(s) or legal representative(s) of each potential subject must: 1. Comprehend the study requirements and agree to comply with planned study procedures and visits 2. Provide written consent prior to enrollment and initiation of any study procedures Pediatric assent will be obtained in accordance with the Institutional Review Board/Independent Ethics Committee determination. Exclusion Criteria: 1. Known allergy to eggs, severe allergy (e.g. anaphylaxis) to other components of either vaccine or contraindications to receipt of the comparator IIV4 2. Immunosuppression as a result of an underlying illness or treatment. Note: Subjects on nasal or topical steroids will be allowed 3. Active neoplastic disease or a history of any malignancy. 4. History of receiving influenza vaccine within the past 6 months or plans during the study to receive influenza vaccine outside of this study. 5. History of receiving immunoglobulin or other blood product within the 3 months prior to enrollment in this study. 6. Receipt of any non-study licensed vaccines within 2 weeks (for inactivated vaccines) or 4 weeks (for live vaccines) prior to enrollment in this study, or plans during the study to receive a licensed vaccine within 4 weeks of a study dose \[See above for influenza vaccines\]. 7. Acute or chronic medical condition that, in the opinion of the investigator, would render immunization unsafe or would interfere with the evaluation of immune responses 8. History of severe reactions following immunization. 9. An acute illness, including a body temperature greater than 100\*F, within 3 days prior to immunization. 10. Receipt of an experimental vaccine or medication within 1 month prior to enrollment in this study, or expectation of receiving an experimental vaccine, medication, or blood product during the study Stage in which the subject will participate. 11. Developmental delay, neurologic disorder, or seizure disorder requiring ongoing medical management (note: history of seizure is not an exclusion criterion). 12. Any other condition or situation that would, in the opinion of the investigator, place the potential subject an unacceptable risk of injury or render the subject unable to meet the requirements of the protocol. 13. History of Guillain-Barré syndrome. 14. Known pregnancy, positive urine or serum pregnancy test within 24 hours prior to planned study vaccination, or breast-feeding. 15. Concurrent participation in another clinical trial (in active or follow-up phase).