Effects of Aerobic Training on Exercise Capacity in Patients With Advanced Cirrhosis 2

N/ACompletedNCT01960127

University of Alberta15 enrolled

Overview

Cirrhosis is associated with a reduction in muscle mass and exercise capacity. This has an impact on morbidity and mortality. Regular aerobic exercise training is a proven effective therapy to improve exercise capacity in healthy and clinical populations. The effect of this training has not yet been evaluated in the decompensated cirrhosis patient population. The safety of this intervention also requires further study. Using a randomized controlled design, the investigators aim to determine the safety and efficacy of eight weeks of aerobic exercise training on aerobic capacity, functional performance, and muscle mass in decompensated cirrhosis patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Cirrhosis

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \>18 and ≤ 70 years * Cirrhosis * Child Pugh class B or C * If required, primary or secondary variceal prophylaxis in place Exclusion Criteria: * Post-liver transplantation * Hepatocelluar carcinoma beyond transplant criteria * Active non-hepatocelluar carcinoma malignancy * Significant cardiac disease * Hemoglobin (\<80 g/L) * Oxygen saturation at rest \<95% * Known myopathy * Chronic renal failure on dialysis * Physical impairment making it impossible to ride an exercise bike or treadmill * Orthopedic abnormality preventing exercise training * HIV infection * Patient unwilling to consent to study

Outcomes

Primary Outcomes

Change in peak exercise pulmonary oxygen uptake (peak V02)

Time frame: Baseline (day1) and Study End (8 weeks)

Secondary Outcomes

Change in muscle mass as measured by thigh ultrasound

Time frame: Baseline (day 1) and Study End (8 weeks)

Change in quality of life-Chronic Liver Disease Questionnaire