Galectin-3 Blockade in Patients With High Blood Pressure

Inclusion Criteria: * Age 21-70 years * Physician diagnosed hypertension on stable therapy for 3 months * Elevated galectin-3 level (above sex-specific median based on Framingham Heart Study measures) * Able to understand the protocol and provide informed consent in English Exclusion Criteria: * Uncontrolled hypertension, defined as systolic blood pressure \> 170mmHg, diastolic blood pressure \> 100mmHg * Evidence of secondary hypertension * History of heart failure, coronary artery disease, stroke, atrial fibrillation * Left ventricular ejection fraction \< 45% on echocardiography * Use of aldosterone antagonists * History of liver cirrhosis * History of pulmonary fibrosis * Kidney dysfunction, defined as estimated glomerular filtration rate \< 45 ml/min/1.73m2 * Anemia, defined as hematocrit \< 37% in men and \< 34% in women * Use of chelating agents * History of Active cancer or malignancy * Known pregnancy, those unwilling to avoid pregnancy during the course of the study, or women currently breastfeeding * Hyperkalemia on screening labs, defined as potassium \>5.2 * Anticipated inability to complete or comply with study protocol * History of angioedema