Postprandial VLDL-TG Metabolism

N/ACompletedNCT01961024

University of Aarhus21 enrolled

Overview

In thise study, we aim to determine the effect of meal fat on VLDL-TG kinetics in type 2 diabetic and healthy subjects matched for BMI in order to elucidate the potential pathophysiological differences in VLDL-TG FA channeling towards oxidation and storage in abdominal and leg subcutaneous adipose tissue. Specifically, we want to measure, by way of fat and muscle biopsies, the quantitative postprandial storage of VLDL-TG FA's in skeletal muscle and adipose tissue in relation to a series of tissue specific proteins and enzymes that might be involved in regulating skeletal muscle and adipose tissue FA storage.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Type 2 Diabetes

Eligibility

Sex: MALEMin age: 30 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Written consent Exclusion Criteria: * Known diseases * Alcohol abuse * Smoker * Regular use of medicine

Locations (1)

Department of Endocrinology MEA, Aarhus Hospital

Aarhus C, Please Select, Denmark

Outcomes

Primary Outcomes

VLDL-TG storage in adipose tissue

Time frame: 3 hours

Secondary Outcomes

18F-THA fractional storage

Time frame: 6 Hours

Data from ClinicalTrials.gov

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