In this clinical cross-over study, we will compare the efficacy of different oral nutrition regimens for night-time glucose control in adult GSD 1 patients. Three different over-night nutrition regimens (=interventions) will be compared in each patient sequentially, (1) uncooked corn starch (UCSS, "Maizena"), (2) modified corn-starch, (3) other carbohydrate (starch) containing meal. During each intervention, glucose profiles will be continuously monitored by continuous glucose monitoring (CGMS). The duration of each intervention is 3d (mimimum) to 6d (maximum), depending on the quality of night-time glucose control and the technical quality of glucose sensor readings. Between the interventions, the patients follow their normal prescribed diet.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
5
Patients receive the specified overnight nutrition regimen
University Hospital Zurich, Division of Endocrinology, Diabetes and Clinical Nutrition
Zurich, Canton of Zurich, Switzerland
Maximum fasting time over-night (h)
Time frame: Maximum fasting time will be measured during each dietary intervention for an average period of 3d (minimum) to 6d (maximum)
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