Effect of AcceleDent® Aura on Orthodontic Tooth Movement With Aligners

Inclusion Criteria: * Males or females between and including the ages of 18 and 40 yo desiring orthodontic treatment that could be completed within two years of treatment with either fixed appliances or aligner treatment. Subjects may have had previous orthodontic procedures. * Adult dentition with all upper front teeth present and any premolar and molar combination in the upper posterior of two teeth on each side. * At least one upper maxillary central incisor that is positioned to allow anterio-posterior (AP) movement (crown tipping only) of 1.98 mm. * Normal pulp vitality and healthy periodontal tissues as determined by intraoral exam. * Good health as determined by medical history. * Willingness and ability to comply with study procedures, attend study visits, and complete the study. * The ability to understand and sign a written informed consent form, which must be signed prior to initiation of study procedures. Exclusion Criteria: * Severe malocclusions that would take longer than 2 years of treatment or require surgical intervention. * Significant periodontal disease (\> 3mm pocket depth or \>1 mm of recession on upper anterior teeth). * Active caries not under care of either a dentist or periodontist. * Chronic daily use of any non-steroidal anti-inflammatory medication, estrogen, calcitonin, or corticosteroids. * History of use or current use of any bisphosphonate medication or other medication for treatment of osteoporosis. * Current smoker (must not have smoked in the last 6 months). * Women may not be pregnant. Negative urine pregnancy tests prior to exposure to cone beam imaging is required to verify pregnancy status. * Any condition or use of medication which in the opinion of the investigator interferes with the biology of tooth movement. * Any condition which in the opinion of the investigator results in increased risk to the subject.