Lorcaserin for Weight Loss Management in Patients on Antipsychotics: A Pilot Study

INCLUSION CRITERIA: * Patients currently on atypical antipsychotics * The patient's BMI is greater than or equal to 30 kg/m2 OR the patient's BMI is greater than or equal to 27 kg/m2 in the presence of at least one weight-related co-morbidity such as hypertension, type 2 diabetes mellitus, dyslipidemia, metabolic syndrome, obstructive sleep apnea, or degenerative joint disease such as osteoarthritis. * Patient agreeable to follow up with provider at the scheduled appointments at week 1, week 2, week 4, week 8, week 12 and week 16 after initiation of medication. EXCLUSION CRITERIA: * Pregnancy in women or breastfeeding * The patient has greater than mild aortic valve regurgitation, or moderate to greater mitral valve regurgitation * Known hypersensitivity to lorcaserin * The patient is taking another weight loss medication concurrently * Dementia * Age less than 18 or greater than 65 * No recent substance abuse within 3 months * No suicidal ideation within 3 months * Unable to give informed consent, unless patient is conserved, then the conservator can provide informed consent