Acute, randomized, placebo controlled, double blind, postprandial crossover study in male subjects. 4 intervention arms consisting of control, orange juice, whole orange, and processed whole orange to determine the effect of the interventions on the primary measure of flow mediated dilatation (FMD) and additional biomarkers of health. The study will also identify and quantify the main micronutrients and phytochemicals in each of the products and will identify and quantify the main micronutrients and phytochemicals and their metabolites in the subjects' plasma and/or urine. A subset of the study population (n=24) will be invited to participate in an additional arm of the main study which is summarised below.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Enrollment
34
University of Reading
Reading, Berkshire, United Kingdom
Flow mediated dilation
Time frame: change in Flow Mediated Dilation response between baseline and 6 hours
Postprandial plasma glucose
Time frame: change in glucose from baseline to 2 hours
Postprandial insulin
Time frame: change from baseline to 2 hours
global cognitive function
Time frame: change from baseline to 6 hours
Blood pressure
Time frame: change from baseline to 6 hours
postprandial non-esterified fatty acids
Time frame: change from baseline to 6 hours
Postprandial triacylglycerol
Time frame: change from baseline to 6 hours
total HDL/LDL
Time frame: change from baseline to 6 hours
Inflammatory status (IL1-beta; IL2; IL6; IL10; IFN-gamma; TNF-alpha; CRP)
Time frame: change from baseline to 6 hours
LDL oxidation
Time frame: change from baseline to 6h
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