The study aimed to evaluate the chronic effects of resistance training on blood pressure and biochemical exams in hypertensive elderlies and the influence of the polymorphism of the angiotensin converting enzyme in these response.
To investigate the chronic effects of resistance training on blood pressure and biochemical exams in elderly, 135 hypertensive elderlies were divided into 2 groups: trained and control. The trained group was submitted to a resistance training period. Before the 16 weeks ACE gene was genotyped (PCR). Before and after 16 weeks, blood pressure (ambulatory), HDL-cholesterol, Total cholesterol, Glycemia, Triacylglycerol (colorimetric assay) and plasminogen activator inhibition (PAI-1), intercellular adhesion molecule (ICAM-1), vascular endothelial cell adhesion molecule (VCAM-1), Adiponectin, tumor necrosis factor alpha (TNF-alpha), C Reactive Protein, Angiotensin II, Angiotensin Converting Enzyme, Angiotensin 1-7, (ELISA assay) were measured.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
136
Resistance training performed three times at week for 16 weeks, in 8 exercises for the main muscles, the protocol of 3 sets of 10 repetitions with intensity of 50% of 1 maximum repetition (MR).
UNIMED
Santos, São Paulo, Brazil
Blood Pressure
Blood pressure was measured by Ambulatorial Monitoring Blood Pressure before and after 16 weeks of intervention.
Time frame: 16 weeks
HDL-cholesterol
HDL-cholesterol was analyzed by colorimetric assay, before and after 16 weeks of intervention.
Time frame: 16 weeks
Total Cholesterol
Total cholesterol was analyzed by colorimetric assay, before and after 16 weeks of intervention.
Time frame: 16 weeks
Glycemia
Glycemia was analyzed by colorimetric assay, before and after 16 weeks of intervention.
Time frame: 16 weeks
Triacylglycerol
Triacylglycerol was analyzed by colorimetric assay, before and after 16 weeks of intervention.
Time frame: 16 weeks
PAI-1
PAI-1 was analyzed by ELISA assay, before and after 16 weeks of intervention.
Time frame: 16 weeks
ICAM-1
ICAM-1 was analyzed by ELISA assay, before and after 16 weeks of intervention.
Time frame: 16 weeks
VCAM-1
VCAM-1 was analyzed by ELISA assay, before and after 16 weeks of intervention.
Time frame: 16 weeks
Adiponectin
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Adiponectin was analyzed by ELISA assay, before and after 16 weeks of intervention.
Time frame: 16 weeks
TNF alpha
TNF alpha was analyzed by ELISA assay, before and after 16 weeks of intervention.
Time frame: 16 weeks
C Reactive Protein
C Reactive Protein was analyzed by ELISA assay, before and after 16 weeks of intervention.
Time frame: 16 weeks
Angiotensin II
Angiotensin II was analyzed by ELISA assay, before and after 16 weeks of intervention.
Time frame: 16 weeks
Angiotensin Converting Enzyme
Angiotensin Converting Enzyme was analyzed by ELISA assay, before and after 16 weeks of intervention.
Time frame: 16 weeks
Angiotensin 1-7
Angiotensin 1-7 was analyzed by ELISA assay, before and after 16 weeks of intervention.
Time frame: 16 weeks