The aim of this study is to evaluate the potential benefits in implantation, clinical pregnancy and live birth rates by an endometrial biopsy prior to an IVF/ICSI treatment. Including a follow up on possible pregnancy complications and data on children at birth. Further it is planned to aspirate secretions from the uterus and take blood samples during the treatment, which presumably can provide information about the mechanisms underlying the possible effect of the treatment.
Randomized controlled prospective clinical study.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
300
The endometrial biopsy will be done in the luteal phase (cycle day 18-22) prior to the treatment cycle (antagonist)
Fertility Clinic, Dronninglund Hospital (Aalborg University Hospital)
Dronninglund, Denmark
RECRUITINGFertility Clinic, Horsens Hospital
Horsens, Denmark
RECRUITINGFertility Clinic, Skive Hospital
Skive, Denmark
RECRUITINGRate of clinical pregnancy
Time frame: Individual outcome will be evaluated within 8 weekes after embryo transfer. Overall outcome will be evaluated after 3 years.
Rate of biochemical pregnancy
Time frame: Individual outcome will be evaluated within 8 weeks after embryo transfer. Overall outcome will be evaluated after 3 years.
Rate of implantation
Time frame: Individual outcome will be evaluated within 8 weekes after embryo transfer. Overall outcome will be evaluated after 3 years.
Rate of live birth
Time frame: Individual outcome will be evaluated within 9 months after embryo transfer. Overall outcome will be evaluated after 3 years.
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