Preload dependence assessment is difficult during prone position, and to date, no hemodynamic parameters have been validated to rationalize fluid loading in that position. This study aims to validate several hemodynamic parameters, using continuous cardiac output by pulse contour analysis and transpulmonary thermodilution.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
33
Hôpital de la Croix Rousse
Lyon, France
Area under ROC curve of the variation in continuous cardiac output during Trendelenburg position, to detect preload dependence
Preload dependence is assessed by the response in cardiac output to a 500 mL fluid loading, and is deemed positive if cardiac output increase by at least 15%
Time frame: 1 minute after Trendelenburg position onset.
Area under ROC curve of the variation in continuous cardiac output during end-expiratory occlusion to detect preload dependence
Preload dependence is assessed by the response in cardiac output to a 500 mL fluid loading, and is deemed positive if cardiac output increase by at least 15%
Time frame: 15 seconds after the onset of end-expiratory occlusion
Area under ROC curve of the respiratory variation in pulse pressure to detect preload dependence
Preload dependence is assessed by the response in cardiac output to a 500 mL fluid loading, and is deemed positive if cardiac output increase by at least 15%
Time frame: 1 minute after tidal volume increase to 8 ml/kg
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