SGI-110 in Combination With an Allogeneic Colon Cancer Cell Vaccine (GVAX) and Cyclophosphamide (CY) in Metastatic Colorectal Cancer (mCRC)

Inclusion Criteria: 1. Documented cancer of the colon or rectum who have received and are stable on first or second-line therapy regimens for metastatic colorectal cancer 2. Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 1 3. Adequate organ function as defined by study-specified laboratory tests 4. Must use acceptable form of birth control through the study and for 28 days after final dose of study drug 5. Signed informed consent form 6. Willing and able to comply with study procedures Exclusion Criteria: 1. Currently have or have history of certain study-specified heart, liver, kidney, lung, neurological, immune or other medical conditions 2. Systemically active steroid use 3. Another investigational product within 28 days prior to receiving study drug 4. Major surgery or significant traumatic injury (or unhealed surgical wounds) occurring within 28 days prior to receiving study drug 5. Chemotherapy, radiation, hormonal, or biological cancer therapy within 28 days prior to receiving study drug 6. Pregnant or lactating 7. Unwilling or unable to comply with study procedures