Clinical Outcomes Following Treatment With Systane® Balance in Dry Eye Subjects

Inclusion Criteria: * Must have all of the following in at least 1 eye at Screening: 1. Meibomian Gland Dysfunction (MGD) grading for Expressibility ≤ 2 and Meibum Quality ≤ 2, 2. The average of 3 measures of TFBUT ≤ 5 seconds, and 3. Unanesthetized Schirmer I test of ≥ 3 mm. * Must have an Ocular Surface Disease Index (OSDI) Score ≥ 18 at Visit 1 prior to randomization (ie, after 2 weeks of run-in with Preservative-Free 0.9% Saline administered 4 times a day). * Must have best-corrected visual acuity of 55 letters or better in each eye as assessed using an early treatment diabetic retinopathy study (ETDRS) chart (letter read method). * Physician diagnosis of dry eye at least 6 months prior to Screening visit. * Willing and able to attend all study visits. * Must sign a written informed consent form. * Other protocol-defined inclusion criteria may apply. Exclusion Criteria: * Subjects on topical ocular treatments containing benzalkonium chloride (BAK), or other products with known toxicity to the corneal surface, within 30 days of Screening. * Subjects who have started, stopped, or changed a lid hygiene regimen within 30 days of Screening. * Use of any artificial tears/lubricants/gels/rewetting drops within 4 hours of Screening. * Women of childbearing potential are excluded from participating in this study if they met any of the following conditions: * Currently pregnant, or * Test positive for pregnancy at Screening visit, or * Currently breast feeding, or * Are not in agreement to use adequate birth control methods to prevent pregnancy throughout the study. * Hypersensitivity to the use of any of the study products or allergy to any ingredient in the study products. * Has an active ocular allergy. * Any ocular abnormalities that could adversely affect the safety or efficacy outcome, including eyelid anomalies, corneal disorders, history of herpes simplex, etc. * Subjects taking any systemic medication known to cause dry eye unless they have been on stable therapy/dosage for at least 30 days prior to Screening and will remain on a stable dosage for the duration of the study. * History of any ocular or intraocular surgery (including periocular Botox injections), eyelid surgery, keratorefractive procedure, corneal transplant and its variants, or serious ocular trauma within 1 year of Screening. * Active ocular infection (bacterial, viral or fungal), active inflammation not associated with dry eye such as uveitis, iritis, active blepharitis, active allergic conjunctivitis, etc. * Subjects with punctal plug insertion or diathermy procedure initiated within 30 days of Screening. * Any significant illnesses that could be expected to interfere with the study parameters. * Subjects with active oculodermal rosacea with meibomian gland dysfunction. * Participation in an investigational drug or device trial within 30 days of Screening. * Contact lens use within 30 days prior to Screening, or unwilling to avoid contact lens use during the course of the study. * Unwilling to avoid the use of additional artificial tears/lubricants/gels/rewetting drops (other than the assigned study medication) throughout the course of the study. * Other protocol-defined exclusion criteria may apply.