Biological Evaluation of Dietary Supplement Liposomal Glutathione

Inclusion Criteria: * Age range: 18-60 * DSM diagnosis of schizophrenia spectrum disorder, including schizophrenia, schizoaffective disorder, and schizophreniform disorder * Ability to give written informed consent (Evaluation to Sign Consent score 10 or greater) * Clinically stable with no change in antipsychotic medications nor significant increase of daily dose for 2 weeks prior to enrollment * Low baseline blood glutathione level (GSH \< 890 umol/l) Exclusion Criteria: * History of major medical illness including, but not limited to, history of heart attack, stroke, TIA (transient ischemic attack) * History of organic brain disorders that may affect neurophysiological measurements, including seizure disorder, brain tumor, head injury with evidence of significant cognitive deterioration * DSM diagnosis of substance dependence within 6 months except nicotine and marijuana, or substance abuse in past month * Uncontrolled blood pressure (persistent systolic above 165 or diastolic above 100) * On medication containing cholesterol absorption inhibitor such as ezetimibe (Brand names Zetia, Ezetrol, Vytorin, and Inegy) * Women who have positive urine pregnancy tests * Women who plan to become pregnant, or are breastfeeding * Unable to undergo MRI scanning due to metallic devices or objects or claustrophobia * Already taking dietary antioxidant supplements such as n-acetylcysteine or fish oil on regular basis (more than twice a week) in the last 3 months * History of allergy to soy or soy products * Hyperlipidemia (baseline LDL \> 1.5 x upper limit of normal) * Liver impairment (baseline AST or ALT \> 2.0 x upper limit of normal)