Nicotine Pharmacokinetic Profile and Safety of the Tobacco Heating System 2.2 (THS 2.2)

Inclusion Criteria: * Subject is Caucasian * Smoking, healthy subject as judged by the Investigator. * Subject has smoked at least 10 commercially available non menthol CCs per day (no brand restrictions) for the last 4 weeks. * Subject has smoked for at least the last 3 consecutive years. * Subject does not plan to quit smoking in the next 3 months. Exclusion Criteria: * As per Investigator judgment, the subject cannot participate in the study for any reason (e.g., medical, psychiatric, and/or social reason). * Subject has received medication within 14 days or within 5 half-lives of a drug (whichever is longer) which has an impact on CYP2A6 activity. * Female subject is pregnant or breast feeding. * Female subject does not agree to use an acceptable method of effective contraception.