A Bioavailability and Pharmacokinetic Study of GDC-0032 in Healthy Volunteers

Inclusion Criteria: * Body Mass Index (BMI) 18 to 32 kg/m2, inclusive; * Healthy, as judged by physician from medical history, 12-lead ECG, vital signs, and clinical laboratory evaluations; * Agree to use effective contraceptive methods as defined by protocol; * Negative hepatitis panel and HIV screen; * Sufficient bowel movements (minimum of 1 per day). Exclusion Criteria: * History or clinical manifestation of: any major medical disorders; any food/drug/substance allergies; * History of stomach or intestinal surgery or resection except for appendectomy and/or hernia repair; * History of alcoholism or drug addiction within 1 year prior to drug administration; * Tobacco or nicotine use within 6 months prior to study start; * Chronic use of gastric acid inhibitors within 6 months of study start or use of gastric acid inhibitors and/or antacids within 1 month prior to drug administration; * Evidence of malabsorption syndrome or other condition interfering with gastrointestinal absorption; * Inability or unwillingness to swallow capsules; * Participation in a drug study in which a drug was administered within 30 days prior to study start; * Participation in more than one radiolabeled drug study within 12 months preceding drug administration. The previous radiolabeled study drug must have been received more than 6 months prior to this study, and the total exposure from this study and the previous study is less than 5000 mrem whole body annual exposure; * Exposure to significant radiation within 12 months prior to study start.