Mechanisms of Ultra-acute Hyperglycemia After Successful Resuscitation From Out-of-hospital Cardiac Arrest

N/ACompletedNCT01968148

Helsinki University Central Hospital30 enrolled

Overview

The aim of the study is to describe the mechanisms of ultra-acute hyperglycemic response after return of spontaneous circulation (ROSC) in patients suffering out-of-hospital cardiac arrest. The investigators hypothesize that ischemia and reperfusion injury leads decreased secretion of insulin and glucose-like peptide 1 (GLP-1). Two blood samples will be drawn: (1.) Immediately after ROSC and (2.) 60 minutes after first sample. Concentrations of glucose, insulin, glucagon and GLP-1 will be compared between the samples. Metabolic profile will be compared between: (1.) diabetic and non-diabetic patients and (2.) survivors and non-survivors.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Heart Arrest Cardiac Arrest

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age ≥18 years * witnessed cardiac arrest * interval form emergency call to return of spontaneous circulation 10-45 minutes Exclusion Criteria: * severe pre-arrest disability leading to withdrawing treatment in prehospital phase * no concent from next of kin

Locations (2)

Outcomes

Primary Outcomes

Change in level of insulin

Time frame: 60 minutes

Change in level of glucagon

Time frame: 60 minutes

Secondary Outcomes

Blood cortisol level

Time frame: 60 minutes after ROSC

Blood interleukin-6 level

Time frame: 60 minutes after ROSC

Change in blood glucose level

Time frame: 60 minutes

Change in level of GLP-1

Time frame: 60 minutes