Neurobiological Aspects of the Attention Deficit Hyperactivity Disorder

N/ACompletedNCT01968512

Federal University of Bahia60 enrolled

Overview

Evaluating neurobiological disorder associated with Attention Deficit Hyperactivity Disorder (ADHD) and the contribution of transcranial direct current stimulation (tDCS) in the adaptation of inhibitory control.

1. Assess the neurobiological aspects evidenced by the amount of brain electrical activity observed by the amplitude of waves through graphs in patients with ADHD, using quantitative electroencephalography; 2. Study the contribution of transcranial direct current stimulation compared with sham in the adequacy of inhibitory control in ADHD patients through neuropsychological test-Go/No Go; 3. Assessing the efficacy of tDCS in neurobiological parameters evidenced by quantitative EEG in patients with ADHD; 4. Perform the Reconstruction of the Functional Brain Network of each subject based on the quantitative EEG data through computational and mathematical modeling; 5. Register indicators of quality of life in adults with Attention Deficit Hyperactivity Disorder through the Quality of Life Questionnaire for Adults with ADHD (AAQoL).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Attention Deficit Hyperactivity Disorder

Interventions

Transcranial Direct Current StimulationDEVICE

This technique consists in the use of low voltage electric current to increase or reduce neuronal excitability in the area stimulated. This is a non-invasive and safe intervention having infrequent and insignificant side effects characterized by mild local discomfort, itching, tingling and/or headache of short term.

ShamDEVICE

Same character of Transcranial Direct Current Stimulation but without current

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Signature of the informed consent; * Diagnosis of Attention Deficit Hyperactivity Disorder based on DSM-IV-TR and Adult Self-Report Scale (ASRS-18); * Adequate eyesight and hearing (or usual corrective methods such as glasses or hearing aid) that allows performing neuropsychological test and questionnaires; * Residents in Bahia/Brazil; * Over 18 years. Exclusion Criteria: * Major psychiatric disorders such as schizophrenia and bipolar disorder; * Inability to understand the questionnaires used or illiterate; * Abuse of psychoactive substances, except nicotine and caffeine, in the last 12 months.

Locations (1)

Federal University of Bahia

Salvador, Estado de Bahia, Brazil

Outcomes

Primary Outcomes

Quantitative electroencephalography

Quantitative electroencephalography to assess the neurobiological aspects evidenced by the amount of brain electrical activity observed by the amplitude of waves through graphs.

Time frame: During the only day of the assessment, we will do it before (during 8 minutes) and after (during 8 minutes more) tDCS

Secondary Outcomes

Functional Brain Network

Functional Brain Network based on the quantitative EEG data through computational and mathematical modeling. During the only day of the assessment, we will do it before (we will get this information from EEG recording during 8 minutes before do the stimulation) and after tDCS(we will get this information from EEG recording during 8 minutes after the stimulation).

Time frame: During the only day of the assessment, we will do it before and after tDCS

Data from ClinicalTrials.gov

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