The proposed study will assess the ability of curcumin, the active ingredient in the Indian spice tumeric, to improve the function of arteries with age. Overall, the proposed research project has the long-term potential to influence clinical practice guidelines by establishing a novel, easy to deliver, cost-effective therapy for treating age-associated arterial dysfunction and reducing the risk of cardiovascular disease with age.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
118
University of Colorado Boulder, Clinical Translational Research Center
Boulder, Colorado, United States
Arterial Stiffness
Arterial pulse wave velocity
Time frame: 12 weeks
Nitric-oxide mediated endothelium-dependent dilation
flow-mediated dilation and forearm blood flow responses to acetylcholine in the presence and absence of N'-monomethyl-L-arginine
Time frame: 12 weeks
Systemic oxidative stress and inflammation
circulating markers of oxidative stress and inflammation
Time frame: 12 weeks
Endothelial cell oxidative stress and inflammation
inflammatory and oxidative stress markers in biopsied vascular and arterial endothelial cells
Time frame: 12 weeks
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