Diagnosing Adverse Drug Reactions Registry

Inclusion Criteria: * Subject has care coordinated at the treating physician's outpatient clinic; * Subject has provided written informed consent; * Subject is taking at least three (3) regularly scheduled medications, excluding as needed (PRN) medications, over the counter medications and nutritional supplements; two (2) of which are known to be affected by genetic allelic variation. * Subject's treating physician has a clinical suspicion that the subject is experiencing adverse signs or symptoms related to a prescribed medication or is not achieving the intended effect from the medication. Exclusion Criteria: * Subject has a history of chronic renal dysfunction, Chronic Kidney Disease Stage 4 or 5; * Subject has a history of abnormal hepatic function within the last 2 years (INR \>1.2 not attributable to anticoagulant medications, AST (aspartate aminotransferase) or ALT (alanine aminotransferase) \>1.5x normal, or suspected cirrhosis); * Subject has a history of malabsorption (short gut syndrome); * Subject has a history of any gastric or small bowel surgery; * Subject is currently hospitalized; * Subject is currently being treated with intravenous medication; * Subject underwent prior pharmacogenomic testing with results reported within the last 12 months. Subjects may be eligible within 60 days from the date of pharmacogenomic testing.