Laser Therapy Treatment of Peri-implantitis.

Inclusion Criteria: * Patients, aged 18 - 85 years * Physical status according to the American Society of Anesthesiologists (ASA) I or II, which includes patients who are systemically healthy or suffer under mild to moderate, but well controlled systemic diseases. * Patients having a minimum of 1 dental implant with peri-implantitis. * The dental implant with peri-implantitis has ≥ 3 threads exposed or pocket probing depth (PPD) ≥ 5mm, with bleeding on probing (BOP) and/or suppuration (pus). * The implants are in function for at least 6 months * No uncontrolled systemic disease or condition known to alter bone metabolism, like Osteoporosis, Osteopenia, Hyperparathyroidism, Paget's disease. * Only rough surface implant will be included in this study Exclusion Criteria: * Long-term use of antibiotics \> 2 weeks in the past two months * No peri-implantitis treatment in the last 2 months * Patients taking medications known to modify bone metabolism (such as bisphosphonates, corticosteroids, Hormone replacement therapy for menopausal women, Parathyroid hormone, Denosumab, strontium ranelate). * Pregnant females or those planning to become pregnant. * Patients with a history of medically diagnosed oral cancer, bisphosphonate usage, Sepsis or those having adverse outcomes to oral procedures in the past, will be excluded * Mobility of dental implants * History of alcoholism or drug abuse * Current smokers or quit smoking less than 6 months * Diseases of the immune system or any medical condition that may influence the outcome (uncontrolled diabetes (HbA1c \>7) * Patients with allergies known to affect one or more of the treatment provided in this study * Polish surface implants * Implants with trabecular surface