The Usefulness of Postprandial Triglyceride for Assessment of Cardiovascular Risk

N/ACompletedNCT01972542

Seoul National University Bundang Hospital80 enrolled

Overview

The hypertriglyceridemia at fasting status has been known to be an important risk factor for cardiovascular disease (CVD). Recently, postprandial triglyceride (TG) levels draw an attention as a superior predictor of CVD because of non-fasting state for more than 12 hours and importance of triglyceride-rich lipoprotein. We aim to investigate the relationship of postprandial triglyceride after fat tolerance test and intima-medial thickness and to suggest normal reference of postprandial triglyceride after fat tolerance test. In addition, we evaluate the correlation of postprandial triglyceride and incretin secretion after fat tolerance test Ultimately, we want to estimate clinical importance of postprandial triglyceride in assessment of cardiovascular risk.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

SCREENING

Masking

NONE

Enrollment

Conditions

Diabetes Prediabetes

Interventions

Eligibility

Sex: ALLMin age: 19 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age : 19 \~ 70 yrs * Type 2 diabetes : HbA1c \<10% * Prediabetic state : HbA1c 5.7\~6.4% Exclusion Criteria: * Type 1 diabetes, secondary diabetes * dipeptidyl peptidase-4 -inhibitor, glucagon-like peptide-1 agonist, thiazolidinediones users * Thyroid disease with abnormal thyroid function test * Liver disease with abnormal liver function test * severe kidney disease * pregnant or lactating women * current smoker * severe obesity

Outcomes

Primary Outcomes

Changes of Triglyceride

Blood sample : drawn by a catheter before the meal and every 1 hour after meal over the 8-hour period

Time frame: 8 hours

Secondary Outcomes

Changes of incretin