This is a single-center, open-label, randomized controlled trial. Patients scheduled for aortic valve replacement (AVR) at Karolinska University Hospital in Stockholm, Sweden will be eligible. Forty patients will be randomly assigned to either minimally invasive (20 patients) or conventional AVR (20 patients). CE-marked and FDA-approved mechanical and bioprosthetic aortic valves (conventional stented or sutureless bioprostheses) will be implanted. Transthoracic echocardiography will be performed before surgery, and at day 1, 4, and 40. Echocardiographic parameters as well as preoperative clinical characteristics and postoperative clinical outcomes will be registered. Routine blood sampling will be performed pre- and postoperatively. All available data will be collected prospectively. Informed consent will be obtained from patients meeting the inclusion criteria before the initiation of any study-specific procedures.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
40
Department of Cardiothoracic Surgery and Anesthesiology, Karolinska University Hospital
Stockholm, Sweden
Tricuspid Annular Peak Systolic Excursion (TAPSE)
Time frame: Preoperatively and postoperatively at day 4 and 40
Right ventricular fractional area change
Time frame: Preoperatively and postoperatively at day 4 and 40
Right ventricular dimensions
Time frame: Preoperatively and postoperatively at day 4 and 40
Pulsed wave tissue Doppler right venricular velocity
Time frame: Preoperatively and postoperatively at day 4 and 40
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.