The aims of this study were to investigate the feasibility of methylprednisolone rotation as treatment of DIH.
we planned a randomized prospective trial for cancer patients with DIH. The objective of the present study was to determine whether the rotation of corticosteroids affects the incidence and intensity of DIH without compromising the antiemetic efficacy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
65
Adult patients who experienced DIH within 3 days after the administration of dexamethasone as an antiemetic were screened. Eligible patients were randomly assigned to receive dexamethasone or methylprednisolone as an antiemetic (randomization phase). In the next cycle of chemotherapy, the dexamethasone group received methylprednisolone and vice versa in the methylprednisolone group (crossover phase).
Gyeongsang National University Hospital
Chiram-dong, Jinju-si, Gyeongsangnam-do, South Korea
Chungang University Hospital
Dongjak-gu, Seoul, South Korea
The intensities of hiccups
Clinically assessed every cycles(2-4weeks). The intensities of hiccups were assessed using a NRS.
Time frame: 2 months
The intensities of emesis
CLinically assessed every cycles (2-4weeks) The intensities of emesis were assessed using a NRS.
Time frame: 2 months
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