Cedar Honey in Oral Lichen Planus

Phase 2CompletedNCT01974414

Mashhad University of Medical Sciences36 enrolled

Overview

The study aimed to evaluate the effect of cedar honey in treatment of erosive and atrophic oral lichen planus ( a common oral problem).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Erosive and Atrophic Oral Lichen Planus

Interventions

orally administered cedar honeyDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. clinically and histopathologically confirmed oral lichen planus without dysplasia in histopathologic evaluation 2. Severity of pain≥2 (VAS score) 3. Severity of lesions≥2 (tong prasom criteria) 4. absence of any treatment in the last month 5. absence of kidney or liver diseases( due to systemic administration of fluconazole to both groups) Exclusion Criteria: 1. evidence of lichenoid reaction in clinical or histopathologic assessment 2. loss of follow up 3. pregnant patients 4. diabetic patients 5. any other mucosal disease 6. any severe systemic disease 7. patients who refuse doctor's advice 8. any unexpected adverse effect of honey

Locations (1)

Oral Medicine Department of Mashhad dental School,Oral and Maxillofacial diseases research center

Mashhad, Khorasan Razavi, Iran

Outcomes

Primary Outcomes

severity of lesions

severity of lesions due to thong prasom criteria

Time frame: 4 weeks

Secondary Outcomes

size of lesions

A sterile caulis was used to measure the maximum diameter of erosive and atrophic lesions and the maximum width perpendicular to the maximum diameter was recorded.

Time frame: 4 weeks

Data from ClinicalTrials.gov

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