Hypertension is an important risk factor of cardiovascular (CVD) and renal diseases. Epidemiological studies show that there is a direct relationship between blood pressure and CVD, and cardiovascular mortality increases progressively throughout the range of blood pressure, including the prehypertensive range. There is also evidence from cell and animal studies that shrimp tissue hydrolysates may have higher ACE inhibitory activity than other marine protein hydrolysates. It is hypothesized that Marealis RPC (refined peptide concentrate)will lower systolic blood pressure in subjects with elevated blood pressure.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
144
2 tablets, once per day before noon
2 tablets, once per day before noon
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Change in daytime ambulatory systolic blood pressure from baseline
Time frame: 8 weeks
Change in office systolic blood pressure from baseline
Time frame: 8 weeks
Change in 24-hour and nighttime ambulatory systolic blood pressure from baseline
Time frame: 8 weeks
Change in 24-hour, daytime and nighttime ambulatory diastolic blood pressure from baseline
Time frame: 8 weeks
Changes in 24-hour, daytime and nighttime ambulatory systolic and ambulatory diastolic blood pressure from baseline
Time frame: 4 weeks
Mean ambulatory systolic blood pressure (24-hour, daytime and nighttime)
Time frame: Over 8 weeks
Mean ambulatory diastolic blood pressure (24-hour, daytime and nighttime)
Time frame: Over 8 weeks
Change in office diastolic blood pressure from baseline
Time frame: 8 weeks
Changes in office systolic and office diastolic blood pressure from baseline
Time frame: 2 weeks
Changes in office systolic and office diastolic blood pressure from baseline
Time frame: 4 weeks
Mean Office systolic blood pressure
Time frame: Over 8 weeks
Mean Office diastolic blood pressure
Time frame: Over 8 weeks
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