The aim of this study was evaluate the effects of the oral probiotic Lactobacillus reuteri Prodentis upon the peri-implant health of edentulous patients with dental implants and peri-implant mucositis, establishing comparisons versus implants without peri-implant disease. The hypothesis of the study is that using these probiotics are going to improve the periimplant health.
A double-blind, placebo-controlled, prospective cross-over study was made. All the patients were edentulous and were divided into two groups: A) with no peri-implant disease; B) with peri-implant mucositis affecting one or more implants. Patients with peri-implantitis were excluded. All patients in both groups initially received the oral probiotic Lactobacillus reuteri Prodentis, followed by placebo. Only the supervisor of the study knew this information; clinical examiner and patients were blind. Were studied: crevicular fluid volume, modified plaque index, probing depth, modified gingival index, and concentrations of interleukin 1β, interleukin 6 and interleukin 8, and Bacterial load.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
34
Department of Oral Surgery, University of Valencia
Valencia, Valencia, Spain
Evidence in reduction of plaque index
The Mombelli clasification was used to evaluate the reduction of bacterial plaque. 0: No bacterial plaque; 1: presence of bacterial plaque but not visually; 2: 1/3 part of the implant with bacterial plaque; 3: 2/3 parts or more of the implant with bacterial plaque
Time frame: 28 days using one probiotic tablet/day
Evidence in reduction of bleeding around implants
The Mombelli classification was used to evaluate the reduction of bleeding around implants: 0: no bleeding; 1: a point of bleeding; 2)a line of bleeding; 3: much bleeding
Time frame: 28 days using probiotic tablet/day
Evidence in reduction of probing depth
Was measured in reduction of millimeters of the depth of the implant with a millimeter probe.
Time frame: 28 days using one probiotic tablet/day
Evidence in reduction Interleukin 1β concentration
concentration measured in picograms/milliliter (pg/ml)
Time frame: 28 days using one probiotic tablet/day
Evidence in reduction Interleukin 6 concentration
concentration measured in picograms/milliliter (pg/ml)
Time frame: 28 days using one probiotic tablet/day
Evidence in reduction Interleukin 8 concentration
concentration measured in picograms/milliliter (pg/ml)
Time frame: 28 days using one probiotic tablet/day
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