Seizures are a potential complication of surgical repair of intracranial aneurysms. In order to prevent seizures, many surgeons administer prophylactic anti-epileptic medication during the intra-operative and post-operative period, however, such practice is not supported by clinical data. Retrospective review found the incidence of postoperative seizures was higher in those who received anti-epileptics versus those who did not. The goal is to examine the utility of levetiracetam (Keppra) for seizure prophylaxis in patients undergoing surgical repair of unruptured intracranial aneurysms.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
17
500 mg intravenous dose during the operative case then 500 mg orally twice a day for a total of seven days
IU Health Methodist Hospital
Indianapolis, Indiana, United States
Incidence of Seizure
Reported via patient in follow-up phone call.
Time frame: 6 mo - 1 Year from Operative Procedure
Number of Participants Who Returned to Daily Activities.
The number who had returned to daily activities in the timeframe of 6-12 months, inclusion of those that returned to most of daily activities.
Time frame: 6 months - 12 months
Number of Participants Who Returned to Work
The number who had returned to work in the timeframe of 6-12 months, inclusion of those that returned to part-time.
Time frame: 6 months - 12 months
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