Metabolic Syndrome and Male Infertility

N/ACompletedNCT01974947

Assistance Publique - Hôpitaux de Paris170 enrolled

Overview

Multidisciplinary, multicentric, cross-sectional study on men in infertile couples who conduct their sperm test through their diagnosis of infertility

Assessment of sperm parameters and metabolic syndrome relations in men attending a Reproductive Biomedicine centre for an infertility of their couple. Secondary objectives are to study relationship between sperm parameters and: * adiposity and insulin resistance * inflammation * oxydative stress in blood and semen * hormonal status Innovative parameters will also be assessed to determine the quality of semen (length of fingers, wrist circumference and epigenetics studies)

Study Type

OBSERVATIONAL

Enrollment

170

Conditions

Male Infertility

Interventions

Blood sample, sperm sample and clinical examensOTHER

Blood sample, sperm sample and clinical examens will be done at the day of the inclusion

Eligibility

Sex: MALEMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 to 45 years-old man * man consulting for primary or secondary infertility, with or without earlier notion of paternity * patient insured with a social security scheme * patient who have had a prior medical consultation * patient who have done informed and written consent to participate in the research study Exclusion Criteria: * patient with problems understanding French * patient smoking more than two-pack-a-day * patient monitoring for viral risk. * man with an unidiopathic infertility which may be explained by: 1\) identifiable factors in direct questioning at the sperm analysis: * exposure to toxic products * infectious disease history * pathological anatomical background 2) factors identified at the etiologic investigation: cytogenetic and genetic

Locations (1)

Jean Verdier Hospital

Bondy, France

Outcomes

Primary Outcomes

Number of spermatozoid and their relation with syndrome metabolic parameters

We will measure the parameters of metabolic syndrome (triglycerides, HDL and LDL cholesterol, systolic and diastolic blood pressure, fasting glucose) and correlate them with the number of spermatozoid .

Time frame: Day 0